Ownership Profile

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Fidelity Management & Research Company 18,710,725 14.99 66,122 12/31/17
ClearBridge Investments, LLC 10,984,818 8.80 -455,033 12/31/17
Wellington Management Company, LLP 10,897,033 8.73 -519,326 12/31/17
The Vanguard Group, Inc. 10,106,212 8.10 162,261 12/31/17
Bellevue Asset Management AG 8,393,040 6.73 265,400 12/31/17
BlackRock Institutional Trust Company, N.A. 6,630,464 5.31 -59,056 12/31/17
Baillie Gifford & Co. 6,612,301 5.30 -355,848 12/31/17
Waddell & Reed Investment Management Company 4,530,100 3.63 -12,000 12/31/17
State Street Global Advisors (US) 2,752,542 2.21 -189,279 12/31/17
OppenheimerFunds, Inc. 2,689,981 2.16 -18,426 12/31/17

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Fidelity Growth Company Fund 7,566,086 6.06 -52,028 12/31/17
Vanguard Total Stock Market Index Fund 3,015,033 2.42 12,636 1/31/18
Vanguard Small-Cap Index Fund 2,925,836 2.34 4,620 1/31/18
ClearBridge Aggressive Growth Fund 2,777,852 2.23 -- 12/31/17
Hartford MidCap Fund 2,613,644 2.09 25,805 12/31/17
Fidelity Select Biotechnology Portfolio 2,524,877 2.02 -45,500 12/31/17
Vanguard Health Care Fund 2,258,500 1.81 -138,800 10/31/17
Ivy Science and Technology Fund 2,214,900 1.77 -35,600 12/31/17
Fidelity Series Growth Company Fund 2,104,782 1.69 -129,100 12/31/17
Waddell & Reed Advisors Science and Technology Fund 1,965,100 1.57 -- 12/31/17

* Insider values reflect direct beneficial ownership.

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